Again, that's 2k gold away, unless you start dagger, then it's about 1600. The duo shields would win early and snowball into mid and late. Not to mention you''ll be crazy squishy.
As for mid game
Karma's Q and E would be enough to get out of your range before the 3rd auto, while pretty much canceling one of the crits.
Lulu can cc you, and choose to fight or run afterwards.
Lux doesn't even need to get near you.
Orianna, I'm unsure. Twitch can likely burst her down before she has the chance to fight or run.